Principal Scientist - LC-MS

Principal Scientist – LC-MS

Carlsbad, CA

An exciting opportunity for an experienced Analytical Chemist to join an innovative biopharmaceutical organization developing novel therapeutics.

This position offers an excellent blend of hands-on analytical science, project leadership, and regulatory involvement, with the opportunity to take ownership of projects and potentially build a team.

Primary Responsibilities

• Lead analytical development and QC activities supporting drug substance and finished drug products.


• Develop, optimize, and validate LC-MS and other analytical methods.


• Manage internal projects and external analytical partnerships.


• Oversee release testing, stability studies, and analytical investigations.


• Contribute to regulatory submissions, including INDs, IMPDs, and CMC documentation.


• Work across both R&D and routine QC activities, retaining significant hands-on laboratory involvement.

Primary Qualifications

• PhD with 3+ years or BS/MS with 5+ years of relevant industry experience.


• Strong hands-on LC-MS experience, including method development and validation.


• Experience working in a GMP-regulated pharmaceutical or biotechnology environment.


• Understanding of ICH/FDA guidelines and phase-appropriate analytical methods.


• Experience with oligonucleotides highly desirable; proteins and peptides also of interest.


• Strong project management, communication, and problem-solving skills.

Salary / Benefits

• $140-165K annual base salary (or MORE!) for qualified candidates


• Help with relocation


• Excellent benefits inc. Health/Dental/Vision, 401k with march, etc.

APPLY NOW!